Monday, November 29, 2010

Anti fungal therapies

Amphotericin B
Azoles: block Ergosterol synthesis which is an component of fungal cell wall
Echinocandins: Inhibit glucan synthase which is specific for fungal wall (eg: caspofungin)

Link

Monday, November 15, 2010

Definition of hypersplenism

- Splenomegaly
- cytopenia(s) - usually thrombocytopenia, anemia or neutropenia
- normal or hyperplastic bone marrow
- response to splenectomy

Meckler's Triad

http://www.ncbi.nlm.nih.gov/pubmed/20935623

Friday, November 12, 2010

GAIL model for breast cancer risk assessment

http://www.cancer.gov/bcrisktool/

- age
- age of menses
- age of first child
- first degree relative with breast cancer
- previous breast biopsies
- History of ADH
- race


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