Two common antithyroid drugs used in north America
- propothiouracul (PTU)
- methimazole (tapazole)
PTU is preferred in the treatment of thyroid storm because it acts both on the thyroid and also peripherally
- in the thyroid both drugs inhibit TPO which converts iodide to iodine to be incorporated into thyroid hormone.
- PTU also prevents the peripheral conversion of t4 into the more active T3
Both drugs can cause skin rash. Agranulocytosis is rare but occurs with both
- 0.44% PTU
- 0.12% methimazole
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