- human mAb to human TNF receptor
- 5-7 days until maximal serum concentration
- dosed every week 40mg I'M
- terminal half-life is 2 weeks
Infliximab (Remicade)
- Humanized mouse mAb to human TNF
- terminal half-life is 7-10 days
- dosed every 2-6 weeks 3-10 mg/kg depending on indication
- for Crohns typically 5 mg/kg
Timing after surgery.
- DMARDS can impair healing. For Remicade suggested to wait 6 weeks before elective surgery. For humira ? 2 weeks
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