Diagnostic Criteria for Lynch Syndrome

Amsterdam Criteria (3-2-1):
Amsterdam criteria was developed for research and therefore very specific criteria.
- 3 relatives with colon ca
- 2 generations
- 1 family member <50 yo

Modified Amsterdam and Bethesda criteria were subsequently developed to be further encompassing.

Modified Amsterdam Criteria:
- same as Amsterdam criteria but cancers can also include: colon, small bowel, ureter, renal pelvis and endometrial ca.

Bethesda Criteria:
- Amsterdam criteria or
- 2 cases of HNPCC cancers in 1 pt, including synch or metach CRC
-  Colon CA and 1^st deg relative with CA/adenoma (CA <45, adenoma <40)
-  Colon or endometrial CA <45
-  R sided colon CA with histo undiff, solid, cribiform, signet-cell <45
-  Adenoma <40